Tobramycin: efficacy of intensive therapy
نویسندگان
چکیده
منابع مشابه
Comparative bioavailability and efficacy of fortified topical tobramycin.
Topical treatment of severe ocular infections may require the use of antibiotics fortified in concentration beyond commercially available preparations. The authors studied tear pharmacokinetics, tissue bioavailability, epithelial toxicity, and comparative antibacterial efficacy of topical tobramycin concentrations ranging from 0.3-5.0%. Tear pharmacodynamics demonstrate bioassay-measurable leve...
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The authors compared 24 doses of hourly topical fortified tobramycin (Group A) therapy with a single subconjunctival administration of multivesicular megaliposome-encapsulated tobramycin (Group B) and free subconjunctival tobramycin (Group C) in treating a rabbit model of keratitis caused by Pseudomonas aeruginosa. One cornea each of 50 rabbits was infected with P. aeruginosa for 24 hr. The ani...
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Of note in this volume is the fact that it is dedicated to the memory of Alfred Gilman. He, along with Louis S. Goodman, wrote the first two editions of this text, and he served as an editor until his death in 1984. He will be missed by all those who knew him. Despite Dr. Gilman's untimely death and the addition of two new editors, Theodore W. Rall and Ferid Murad, the book remains unchanged in...
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A patient required mitral valve replacement following ineffective antibiotic treatment of enterococcal endocarditis caused by Streptococcus faecium. Endocarditis had relapsed despite therapy with ampicillin and tobramycin for six weeks. A second relapse had occurred following treatment with penicillin and gentamicin. Initial failure of antibiotic therapy may be related to the known lack of in v...
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BACKGROUND Recent lipid guidelines recommend aggressive low-density lipoprotein (LDL) cholesterol lowering in patients with coronary artery disease. To clarify the evidence for this recommendation, we conducted a meta-analysis of randomized controlled trials that compared different intensities of statin therapy. METHODS We searched electronic databases (MEDLINE, EMBASE, Cochrane Central Regis...
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ژورنال
عنوان ژورنال: Perioperaciina Medicina
سال: 2021
ISSN: 2617-2925,2616-339X
DOI: 10.31636/prmd.v3i2.1